蒋育澄
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职 称：教授(博士生导师)
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毕业学校：中国科学院盐湖研究所
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电 话：029-81530763
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电子邮箱：jyc@snnu.edu.cn
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研究方向：酶工程、生物无机化学
个人简介
主要从事金属蛋白化学(metalloproteins chemistry)及酶工程(enzyme engineering)方面的研究。先后主持国家自然科学基金项目2项、教育部留学回国人员启动基金1项、陕西省自然科学基金项目1项；获得中国发明专利3项；获得陕西省科技进步三等奖1项、陕西省高等学校科技进步奖一等奖1项；参与编写“无机化学”相关教材2部。
目前的研究工作主要集中在： （1）基于氨基酸定位突变及溶剂工程的血红素过氧化物酶的催化活性设计； （2）氯过氧化物酶(CPO) 的活性中心结构及其在不对称环氧化、羟基化反应中对底物的手性识别机理； （3）CPO生物反应器的制备及其在手性中间体的合成和环境毒物降解中的应用。
代表性成果
1. Lixia Liu, Juan Zhang, Yi Tan, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai, Rapid decolorization of anthraquinone and triphenylmethane dye using chloroperoxidase: Catalytic mechanism, analysis of products and degradation route”, Chem. Eng. J., 2014, 244,9
2. Haiyun Li, Jinwei Gao, Limin Wang, Xiaohong Li, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai, Promotion of activity and thermal stability of chloroperoxidase by trace amount of metal ions (M2+/M3+), Appl. Biochem. Biotechnol., 2014, 172, 2338
3. Xuelian Li, Juan Zhang, Yucheng Jiang,* Mancheng Hu, Shuni Li, Quanguo Zhai, Highly efficient biodecolorization/degradation of congo red and alizarin yellow R by chloroperoxidase from Caldariomyces fumago: catalytic mechanism and degradation pathway. Ind. Eng. Chem. Res., 2013, 52, 13572
4. Rixiao Jin, Chaonan Li, Lifei Zhi, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai, Deactivation of chloroperoxidase by monosaccharides (D-glucose, D-galactose, and D-xylose), Carbohydr. Res., 2013, 370, 72
5. Juan Zhang, Mingyue Feng, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai, Efficient decolorization/degradation of aqueous azo dyes using buffered H2O2 oxidation catalyzed by a dosage below ppm level of chloroperoxidase, Chem. Eng. J., 2012, 191, 236
6. 汪丽敏,吴金跃,蒋育澄*,胡满成,李淑妮,翟全国,手性苄基甲基亚砜的氯过氧化物酶催化定向合成,化学学报, 2012, 70(4), 1344
7. Yali Wang, Jinyue Wu, Xuejiao Ru, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai, Catalytic performance and thermostability of chloroperoxidase in reverse micelle: achievement of a catalytically favorable enzyme conformation, J. Ind. Microbiol. Biotechnol., 2011 38, 717
8. Huizhen Zhang, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai, Biotransformation of cyclohexene to value-added oxygenated derivative catalyzed by chloroperoxidase in the presence of small quantities of quaternary ammonium salts, Appl. Catal. A: Gen., 2011, 401, 204
9. Chaonan Li, Limin Wang，Yucheng Jiang*，Mancheng Hu，Shuni Li，Quanguo Zhai，Activity and stability of chloroperoxidase in the presence of small quantities of polysaccharides: A catalytically favorable conformation was induced，Appl. Biochem. Biotechnol., 2011, 165, 1691
10. Jinyue Wu, Chen Liu, Yucheng Jiang*, Mancheng Hu, Shuni Li, Quanguo Zhai. Synthesis of chiral epichlorohydrin by chloroperoxidase-catalyzed epoxidation of 3-chloropropene in the presence of an ionic liquid as co-solvent. Catal. Commun. 2010, 11: 727
